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Year : 2021  |  Volume : 4  |  Issue : 1  |  Page : 27-30

Platelet-rich plasma improves embryo implantation in women with repeated implantation failures: A quasi-experiment

1 Department of IVF, Parsian Hospital, Tehran, Iran
2 Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran
3 School of Medicine, Islamic Azad University, Tehran, Iran

Correspondence Address:
Dr. Parvin Zareian
Department of Physiology, School of Medicine, AJA University of Medical Sciences, Etemadzadeh Street, Western Fatemi Street, Tehran.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tofj.tofj_2_21

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Background: Various methods have been used for the treatment and management of repeated implantation failures (RIFs). One approach that has recently been considered for the treatment of RIF is intrauterine infusion of platelet-rich plasma (PRP). Objective: In the present study, the effect of intrauterine injection of PRP on pregnancy outcome was investigated in women with RIFs. Study Design: This study was performed on 17 patients with RIF history. The number of embryos (5-day blastocyst) transferred in each patient was 1 or 2. An aliquot of 12 mL of venous blood was taken from the patient. After two centrifugal stages, 0.5–1 mL of PRP was obtained. PRP was injected into the womb cavity. Results: The implantation and clinical pregnancy were confirmed in 35.3% (n = 6) of the patients. One patient had a miscarriage in the second month of pregnancy. Live birth rate was 29.4% (n = 5). Conclusion: This study showed the effectiveness of intrauterine infusion of PRP in patients with RIFs.

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